By Lazaros C. Triarhou (auth.)
ISBN-10: 0306474182
ISBN-13: 9780306474187
ISBN-10: 1461352010
ISBN-13: 9781461352013
ISBN-10: 1461506999
ISBN-13: 9781461506997
This ebook is the end result of fifteen years of analysis at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterised through genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the one on hand laboratory version with a prolonged illness that mimics Parkinson's affliction. Structural and practical points of intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical points of donor mobile survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of unilateral and bilateral neuronal transplantations.
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Extra resources for Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease
Example text
TRIARHOU Figure 10. Electron microscopic immunocytochemistry for tyrosine hydroxylase showing the formation of synapses between unlabeled axon terminals and immunopositive dendrites in the substantia nigra of normal (a), heterozygous weaver (b) and homozygous weaver (c). Magnification x2220a (a), x24200 (b), x2230a (c). Unpublished micrographs by L. C. Triarhou. reticulata of weaver heterozygotes, DA dendrites are reduced by 60% at 20 days of age, when nigral DA neuron number, striatal DA content, and pattern of synaptic connectivity of nigrostriatal axon terminals are all normal.
Golgi-Cox preparations showing varicose dendrites in the substantia nigra pars reticulata of +/ + (a), wv/+ (b) and wv/wv (c) mutant mouse. Note the substantial reduction of varicose size and the elongation of the intervaricose segment in wv/wv. Magnification x150. Unpublished micrographs by the author. homozygous for the wv gene, involving the dendritic DA projection that extends from the substantia nigra pars compacta into the substantia nigra pars reticulata. C. TRIARHOU Figure 10. Electron microscopic immunocytochemistry for tyrosine hydroxylase showing the formation of synapses between unlabeled axon terminals and immunopositive dendrites in the substantia nigra of normal (a), heterozygous weaver (b) and homozygous weaver (c).
Smeyne RJ, Goldowitz D. Development and death of external granular layer cells in the weaver mouse cerebellum: A quantitative study. J Neurosci 1989; 9: 1608-1620. 68. Smeyne RJ, Goldowitz D. Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU). Dev Brain Res 1990; 54:282-286. 69. Wiestler OD, Trenkner E, Walter G. Progressive loss of neuronal src protein in postnatal weaver and staggerer cerebellum. Exp Cell Bioi 1988; 56:190-195.
Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease by Lazaros C. Triarhou (auth.)
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