By Thomas H. Norwood (auth.), Christine K. Cassel M.D., Donald E. Riesenberg M.D., Leif B. Sorensen M.D., Ph.D., John R. Walsh M.D. (eds.)
ISBN-10: 1475720939
ISBN-13: 9781475720938
ISBN-10: 1475720955
ISBN-13: 9781475720952
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Takehara K, LeRoy EC, Grotendorst GR. TGF-/3 inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression. Cell 1987;49:415-422. 27. Eaglstein WHo Wound healing and aging. Dermatol Clin 1986;4:481-484. 28. Siskind GW. Aging and the immune system. In: Warner HR, Butler RN, Sprott RL, et al, eds. Modern Biological Theories of Aging. New York, NY: Raven Press; 1987:235-242. 29. Hefton JM, Darlington GJ, Casazza BA, et al. Immunologic studies of aging, V: impaired proliferation of PHA responsive human lymphocytes in culture.
Therefore, it is important to carry out parallel studies in vivo whenever feasible. The first attempts to quantitate the extent of age-associated change in proliferative activity in vivo were carried out by enumeration of tritium-labeled interphase and mitotic cells in autoradiographic preparations of tissue from laboratory animals that had previously been pulsed with labeled thymidine. This technology permits quantitation of the following phases of the cell cycle: pre-DNA synthesis (G I ), DNA synthesis, post-DNA synthesis (G 2) , and mitosis (M).
In addition, cell function is influenced by 1. Cellular Aging 13 Table 104. Selected stochastic theories of aging, corresponding types of damage, and repair mechanisms. Source, y Rothstein,55 1987 Name of theory Protein error catastrophe Setlow ,56 1987 Somatic mutation Katz and Robison,43 1986; Harman,45 1986 Free-radical Molecular substrate Mechanism of primary change Primary: proteins; secondary: errors of DNA synthesis Primary: DNA; secondary: production of abnormal proteins Random errors of transcription and translation Random errors during replication and repair, damage by physical and chemical mutagens Free-radical damage to macromolecules, eg, lipid peroxidation All macromolecules, lipids most frequently the extracellular matrix that is known to undergo qualitative and quantitative changes with age.
Geriatric Medicine by Thomas H. Norwood (auth.), Christine K. Cassel M.D., Donald E. Riesenberg M.D., Leif B. Sorensen M.D., Ph.D., John R. Walsh M.D. (eds.)
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