By Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden
Mechanical cardiovascular help units has to be accurately designed to prevent harm to the blood they touch. the criteria that have an effect on the hemocompatibility of a cardiovascular help gadget comprise 3 significant non-physiological elements - the fabric, fluid circulate paths, and stream similar stresses, - in addition to the gadget interplay with the local vasculature. additionally, the interplay of the equipment with the blood isn't really static. overseas surfaces turn on blood parts together with platelets, leukocytes and the coagulation cascade. Thrombus formation at the floor of the equipment can regulate the fluid dynamics in a way that motives erythrocyte harm starting from major hemolysis to sub-lethal trauma which may take many days to weeks to turn into an important medical challenge. This sub-lethal blood trauma isn't really simply detectable with out unique gear, that is commonly unavailable in regimen medical perform. Surveillance for blood harm is usually sub-optimal within the medical surroundings, yet as soon as clinically proper hemolysis happens, an important judgements - machine elimination, substitute, or extra scientific treatments together with surgical procedure or plasmapheresis - that bear in mind the risk/benefit of intervention needs to be speedy evaluated. a few of the preclinical designs and trying out, surgical concerns, on hand surveillance strategies, and medical outcomes should be mentioned utilizing contemporary and old case experiences to spotlight key issues.
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The exact mechanism of action for pentoxifylline is not entirely clear but it has been reported to increase red cell deformability and reduce blood viscosity. For these reasons, it is typically used in patients who have arterial occlusive diseases including sickle cell anemia [175]. Apart from pharmacological attempts to increase clearance or increase deformability, a mechanical means of clearance may be necessary to prevent damage to end organs in the case of acute hemolysis. Because of the relatively high molecular weight of the free hemoglobin molecule (64,000 Da or greater depending on dimerization), clearance through standard hemoconcentrators is not feasible.
Kameneva, M. , and Wild, M. , 1994, “Capacity for Red Blood Cell Aggregation Is Higher in Athletic Mammalian Species Than in Sedentary Species,” Journal of Applied Physiology, 77(4), pp. 1790–4. [70] Ami, R. , 2001, “Parameters of Red Blood Cell Aggregation as Correlates of the Inflammatory State,” American Journal of Physiology – Heart and Circulatory Physiology, 280(5), pp. H1982–8. [71] Morariu, A. , Maathuis, M. , Asgeirsdottir, S. , Leuvenink, H. , Boonstra, P. , Ploeg, R. , 2006, “Acute Isovolemic Hemodilution Triggers Proinflammatory and Procoagulatory Endothelial Activation in Vital Organs: Role of Erythrocyte Aggregation,” Microcirculation, 13(5), pp.
141] Zager, R. , and Gamelin, L. , 1989, “Pathogenetic Mechanisms in Experimental Hemoglobinuric Acute Renal Failure,” Am J Physiol, 256(3 Pt 2), pp. F446–55. [142] Antaki, J. , Burgreen, G. , 1995, “Computational Flow Optimization of Rotary Blood Pump Components,” Artif Organs, 19(7), pp. 60815. [143] Burgreen, G. , Antaki, J. , Wu, Z. , and Holmes, A. , 2001, “Computational Fluid Dynamics as a Development Tool for Rotary Blood Pumps,” Artif Organs, 25(5), pp. 336–40. , Throckmorton, A. , Wood, H.
Mechanical Blood Trauma in Circulatory-Assist Devices by Timothy M. Maul, Marina V. Kameneva, Peter D. Wearden
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