By Novartis Foundation
ISBN-10: 047084146X
ISBN-13: 9780470841464
The article of this publication is to assemble jointly employees within the fields of epilepsy, these fascinated about the fundamental technological know-how of resistance and the blood-brain barrier, and people with scientific adventure of drug resistance in melanoma, that allows you to stimulating additional paintings on drug resistance in epilepsy. while resistance in melanoma has been generally studied, and trials of reversal of resistance were undertaken, with a few good fortune, resistance in epilepsy has merely simply started to be addressed.
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Additional resources for Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology
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Although astrocytic Pgp expression is generally undetectable in normal rat brain, up-regulation follows intracerebroventricular injection with neurotoxic concentrations of kainate (Zhang et a1 1999). Taken together, these studies suggest that activation of brain endotheliurn and astrocytes by damage, isolation or stress can alter the transporter phenotype, leading to a condition in which the primary endothelial barrier is supported by a ‘second line of defence’, the astrocytes. There are clearly implications for the epileptic brain and for treatment with AEDs.
Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SP, Deeley RG 1994 Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54:357-361 30 SCHEFFER Clsc SCHBPER Hamada H, Tsuruo T 1986Functional role for the 170-to 180-kDa glycoprotein specificto drugresistant tumor cells as revealed by monoclonal antibodies. -7789 Higgins CF 1992 ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67--113 Honjo Y, Hrycyna CA, Yan QW et a12001 Acquired mutations in the MXR/BCRP/ABCPgene alter substratc specificity in MXRIBCRPIABCP-overexpressing cells.
Immunostaining of normal human liver tissue for MRP6 and MRP2. MRP6 is present at the basolateral membranes of the hepatocytes (a), whereas MRP2 is present at the apical site of the hepatocyte, the canalicular membrane (b). 2000a, Maliepaard et a1 2001, G. L. Scheffer, unpublished results). g. along the gastrointestinal tract and the lung mucosa. At these sites there is a real need to protect the inside against potentially dangerous exogenous compounds, toxic materials, microbial products, etc.
Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology by Novartis Foundation
by David
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