By Alan Soo-Beng Khoo, Kin-Choo Pua (auth.), Pierre Busson MD, PhD (eds.)
ISBN-10: 146145946X
ISBN-13: 9781461459460
ISBN-10: 1461459478
ISBN-13: 9781461459477
This quantity intends to give a contribution to “translational medication and biology”. by means of this, we suggest a bi-directional approach whose objective is to increase wisdom from simple technology in the direction of diagnostic and healing purposes and reciprocally to elevate new questions for uncomplicated scientists. One normal requirement for translational learn is to set up a multidisciplinary wisdom base shared through the actors of varied specialties. this is often exactly the target of the 12 chapters of this e-book. it will likely be important for scientists, together with PhD scholars, who are looking to develop into extra accustomed to the most thoughts of NPC pathology, clinical imaging and present therapeutics. Conversely, docs who are looking to replace their wisdom of NPC biology will reap the benefits of chapters on viral and mobile oncogenesis and numerous facets of host-tumor interactions.
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Additional info for Nasopharyngeal Carcinoma: Keys for Translational Medicine and Biology
Sample text
As with previous studies desmosomes were present but tonofilaments uncommon. Both of these investigators, as well as Prasad, attributed the nuclear changes to an increased metabolic activity of the cells. The conclusion was that the undifferentiated carcinoma was a form of squamous cell carcinoma showing minimal differentiation and evidence of high metabolic activity. 22 WHO correctly emphasized, by definition, that NPC was a malignant neoplasm that has its origin from the epithelial layer of the nasopharynx, an epithelial layer that might be stratified squamous type, ciliated respiratory type, or some gradation between these two extremes.
However, other organ systems (lung, skin, stomach, uterine cervix, breast and bladder) have produced undifferentiated carcinomas with a lymphoid stroma that are microscopically similar to lymphoepithelioma of the nasopharynx. Polymerase chain reaction and in situ hybridization of undifferentiated carcinomas from some of these some of these body sites have been shown to harbour the EB viral genome within the malignant epithelial cells. At the same time as the 1978 WHO classification was being formulated a group of European pathologists met to discuss the classification of NPC.
Am J Roentgenol 1925; 14:529-540. 7. Ewing J. Lymphoepithelioma. Am J Path 1929; 5:99-107. 8. Cappell D. On lymphoepitheliomas of the nasopharynx and tonsils. J Pathol and Bact 1934; 39:49-64. 9. Cappell D. The pathology of nasopharyngeal tumours. J Laryngol Otol 1938; 53:558-580. 10. Salinger S, Pearlman S. Malignant tumours of the epipharynx. Tr Am Acad Ophth 1935; 41:281-316. 11. Thompson E. Lymphoepithelioma of the nasopharynx. AMA Arch Otolaryngol 1951; 54:390-408. 12. Ch‘eng Y. Lymphoepithelioma of the nasopharynx with involvement of the nervous system.
Nasopharyngeal Carcinoma: Keys for Translational Medicine and Biology by Alan Soo-Beng Khoo, Kin-Choo Pua (auth.), Pierre Busson MD, PhD (eds.)
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