By Yan Yang, Wayne N. Frankel (auth.), Devin K. Binder, Helen E. Scharfman (eds.)
ISBN-10: 0306478609
ISBN-13: 9780306478604
ISBN-10: 1417562269
ISBN-13: 9781417562268
Epilepsy study has entered an exhilarating part as advances in molecular research have supplemented in vitro and in vivo electrophysiologic and phenotypic characterization. Recent Advances inEpilepsy Research units forth a chain of bankruptcy experiences by way of researchers all in favour of those advances. This quantity is a composite profile of a few fascinating fresh investigations in opt for components of enquiry.
Key gains: neurogenetics of seizure issues, new advancements in mobile and molecular neurobiology of seizure issues, the position of development elements in seizures, new advances within the roles of metabotropic glutamate receptors and GABA receptors and transporters, hole junctions, neuroimmunology of epilepsy, malformations of cortical improvement, neurogenesis, new animal types of epilepsy and using mind stimulation to regard epilepsy. This ebook may be of curiosity to a large choice of audiences, together with graduate scholars in neurobiology and similar disciplines, neuroscientists, scientific scholars, neurologists, neurosurgeons, and together with pharmaceutical businesses and clinical machine businesses. there are numerous rules during this booklet that may lead creative innovators in academia and to improve new and higher therapies.
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Hughes PE, Pfaff M. Integrin affinity modulation. Trends Cell Biol 1998; 8:359-364. 53. Bouvard D, Molla A, Block MR. Calcium/calmodulin-dependent protein kinase II controls α5β1 integrin mediated inside out signaling. J Cell Sci 1998; 111:657-665. 54. Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nature Cell Biol 2002; 4:83-90. 55. Huang Y-Q, Lu WY, Ali DW et al. CAKβ/PYK2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus.
Humphries MJ, Delwel GO, Kuikman I et al. Integrin structure. Biochem Soc Trans 2000; 28:311-39. 49. Hynes RO. Cell adhesion: old and new questions. Trends Cell Biol 1999; 9:M33-M37. 50. Giancotti FG, Ruoslahti E. Integrin signaling. Science 1999; 285:1028-1032. 51. Dedhar S, Hannigan G. Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Current Opinion in Cell Biology 1996; 8:657-669. 52. Hughes PE, Pfaff M. Integrin affinity modulation. Trends Cell Biol 1998; 8:359-364.
A slightly later stage of consolidation would be expected to incorporate contributions from the α3β1 and α5β1 integrins and to 20 Recent Advances in Epilepsy Research result in a potentiation that is both stable and extremely resistant to interference. 119 In all, the multiple stages of consolidation described for memory may find integrin-based analogues in long-term potentiation. Finally, there is evidence that other classes of adhesion receptors in addition to integrins are involved in stabilizing LTP (see 44,120-122 for review).
Recent Advances in Epilepsy Research by Yan Yang, Wayne N. Frankel (auth.), Devin K. Binder, Helen E. Scharfman (eds.)
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