By Sean V. Murphy, Anthony Atala
ISBN-10: 149871191X
ISBN-13: 9781498711913
Miniaturization within the fields of chemistry and molecular biology has led to the "lab-on-a-chip." Such structures are micro-fabricated units in a position to dealing with super small fluid volumes facilitating the scaling of unmarried or a number of lab tactics right down to a microchip-sized structure. The convergence of lab-on-a-chip know-how with the sector of telephone biology facilitated the advance of "organ-on-a-chip" structures. Such structures simulate the functionality of tissues and organs, having the aptitude to circumvent a few mobilephone and animal checking out tools. those applied sciences have generated excessive curiosity as functions for illness modeling and drug discovery.
This e-book, edited by means of Drs. Sean Murphy and Anthony Atala, offers a entire insurance of the applied sciences which were used to advance organ-on-a-chip structures. identified leaders disguise the fundamentals to the main proper and novel themes within the box, together with micro-fabrication, 3D bio-printing, 3D mobile tradition strategies, biosensor layout and microelectronics, micro-fluidics, information assortment, and predictive research. The e-book describes particular tissue kinds amenable for disorder modeling and drug discovery functions. Lung, liver, middle, pores and skin and kidney "on-a-chip" applied sciences are incorporated in addition to a growth document on designing a complete "body-on-a-chip" method. also, the ebook covers functions of assorted structures for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and offers an outline of present and capability functions of those platforms to illness modeling, toxicity checking out, and individualized medicine.
Read Online or Download Regenerative medicine technology: on-a-chip applications for disease modeling, drug discovery and personalized medicine PDF
Best medicine books
Read e-book online Anatomy of Gene Regulation: A Three-dimensional Structural PDF
Not uncomplicated line drawings on a web page, molecular constructions can now be seen in full-figured glory, frequently in colour or even with interactive percentages. Anatomy of Gene law is the 1st e-book to give the components and procedures of gene legislation on the third-dimensional point. bright buildings of nucleic acids and their better half proteins are published in full-color, 3-dimensional shape.
- Practical Applications of Mechanical Ventilation
- The scientific basis of integrative medicine
- Meningococcal Vaccines: Methods and Protocols
- The Patient's Playbook: How to Save Your Life and the Lives of Those You Love
Additional resources for Regenerative medicine technology: on-a-chip applications for disease modeling, drug discovery and personalized medicine
Example text
Inkjet bioprinting is carried out using inkjet printers, also known as drop-on-demand printers [36]. Here, controlled volumes of liquid are delivered to predefined locations based on digital designs (2D or 3D) created on a computer. The first inkjet-based bioprinters were actually modified, commercially available, 2D ink-based printers in which the ink in the cartridge was replaced with a biological material and printing along a z axis (along with x and y axes) was added to the printer function.
Simultaneous analysis and scaling-up of sample numbers would increase the statistical significance of results obtained from these chips. Controlling long-term survival and enhancing differentiation and function of cells in the chip can be achieved by controlling fluid flow, and this would enable testing or analysis to be carried out on clinically relevant time scales for chronic pathophysiological conditions which are usually for a duration of several weeks. Controlling fluid flow in organs-on-a-chip can enable modeling of absorption, distribution, metabolism, and excretion (ADMET) properties of drugs, which can predict their pharmacokinetic/pharmacodynamic properties more reliably.
Some systems also have multiple bioink cartridges that facilitate serial or parallel dispensing of multiple materials without the need for changing the print head. As the name suggests, extrusion-based direct-write bioprinters dispense materials continuously, and the newly dispensed material has to physically contact the previous layer in order to build the 3D structure. The print pattern is directed by the CAD file, which is converted into instructions for printing using a computer-aided manufacturing (CAM) and printer-specific software.
Regenerative medicine technology: on-a-chip applications for disease modeling, drug discovery and personalized medicine by Sean V. Murphy, Anthony Atala
by Daniel
4.3