The Meaning of It All: Thoughts of a Citizen-Scientist by Richard P. Feynman PDF

By Richard P. Feynman

ISBN-10: 0465023940

ISBN-13: 9780465023943

Many take pleasure in Richard P. Feynman’s contributions to twentieth-century physics, yet few notice how engaged he was once with the realm round him—how deeply and thoughtfully he thought of the non secular, political, and social problems with his day. Now, a superb book—based on a formerly unpublished, three-part public lecture he gave on the college of Washington in 1963—shows us this different facet of Feynman, as he expounds at the inherent clash among technological know-how and faith, people’s mistrust of politicians, and our common fascination with alien craft, religion therapeutic, and psychological telepathy. the following we see Feynman in most sensible shape: approximately bursting right into a Navajo struggle chant, then urgent for an overhaul of the English language (if you must recognize why Johnny can’t learn, simply examine the spelling of “friend”); and, ultimately, ruminating at the dying of his first spouse from tuberculosis. this is often necessary Feynman —reflective, a laugh, and ever enlightening.

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G. E. A. Davies, unpublished observations). Therefore, although HA-l cells may be considered deficient in antioxidant enzymes, our results point to key roles for non-classical proteins (perhaps repair enzymes for DNA, proteins, and lipids) in the adaptive response to H20 2 • This feature of adaptation to oxidant stress also appears important in bacteria where the "late proteins" induced by H20 2 are largely non-antioxidant enzymes. G. E. A. S. V. A. Davies, unpublished observations). Such observations give us sUbstantial confidence that inducible resistance to oxidative stress is a general genetic property of eucaryotic cells.

Have shown that a similar adaptive response to H20 2 is evident in s. , 1985). Similarly, such as 2 - generating compounds, ° paraquat, impart an adapti ve response in E. , 1985). , 1985). Similar analysis in the adaptive response to 02- shows that approximately 40 new polypeptides are synthesized in addition to the 30 to 40 polypeptides induced by H20 2 • (Because H20 2 is produced from the dismutation of 02- one would expect to see the appearance of H20 2 induced polypeptides in the 02- response).

The peroxidation reaction and protein modification was found to be inhibited by both the peroxyl radical scavenger butylated hydroxy-toluene and SOD, but not by catalase. The addition of exogenous peroxide to the LDL particle did not alter the rate of SIN-i-dependent LDL oxidation. From this observation it was concluded that peroxidation is initiated from hydrogen atom extraction rather then the breakdown of existing lipid hydroperoxides. In summary, the authors concluded that LDL is oxidized as result of the simultaneous generation of NO and O2 " in a SOD sensitive but catalase insensitive mechanism caracteristic of the reactions mediated by peroxynitrite.

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The Meaning of It All: Thoughts of a Citizen-Scientist by Richard P. Feynman


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