By Emanuel M. Josephson
This examine deals a scientific resolution of the matter of myasthenia
gravis (MG) and of kindred diseases. And it sheds
light at the functionality of the thymus and its issues. It offers
a particular treatment for these ailments.
The ills which it serves to elucidate and therapy, furthermore to
myasthenia gravis and linked thymus affections, include
paralysis agitans (Parkinsonism), the disorder complicated that is
known as "collagen disease," lupus erythematosus, angioneurotic
edema and asthma. It poses a standard denominator between
these largely different medical photos and the baffiing
problem of muscular and neuromuscular illnesses reminiscent of dermomyositis,
polymyositis, myotonia and the dystrophies, in the
form of a easy, underlying ailment of metabolism.
The effects suggested within the myasthenia gravis situations presented
are of unusual importance. First, they've been characterized,
in luck, via therapy of all of the numerous points of the condition,
including the thymus involvement; and in failure, by way of a
clear-cut clarification of the explanation why. moment, the successes
have stood the try out of time for many years. And final, yet now not least,
the effects were attained with out the danger to existence involved
in the almost immediately "accepted remedy" through cholinergic medicines.
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Additional info for The Thymus, Manganese and Myasthenia Gravis, Incorporating Myasthenia Gravis, Manganese and THF Thymus
Sample text
VITAMIN E & GLYCINE TESTED In spite of the startling results obtained in the treabnent of myasthenia gravis by Dr. Harriet Edgeworth with ephedrine sulphate and by Dr. Mary Walker with physostigmine (107), it appeared unwise to the author, for the reasons above stated, to follow the therapeutic vogue thereby initiated that proved so profitable to some entrepreneurs and fatal to so many victims. In view of the state of biologic science, it appeared to be more rational to approach the study of the disease as a disorder of muscle metabolism and physiology, than as a disturbance of the neural or neuromuscular mechanism for which no substan- olgltlzea by Coogle 36 Origiral from UNIVERSITY OF MICHIGAN tial proof had been adduced, or has yet been adduced.
The authors fail to list what is probably the real reason: the irrationality and inadvised character of the therapy. The "myasthenic" and " cholinergic" crises, and the deaths that they cause, that are an "accepted" feature of the anticholinesterase treatment of myasthenia gravis, are most frequently, in cases so treated, manifestations of poisoning by the therapy. This is acknowledged by Osserman in his MYASTHENIA GRAVIS (108, p. 165) as follows: "Sudden, unexplained death is still not rare in myasthenia gravis .
With pyridostigmine (Mestinon) and ambenonium (Mytelase) the side-eHects are usually, but not invariably, milder. "The side-effects most generally encountered are referable to the gastrointestinal tract: abdominal cramps, increase in peristalsis, diarrhea, nausea and occasional vomiting. Next in frequency are signs of glandular hypersecretion, most commonly of the bronchial mucosa and salivary glands but also occaolgltlzea by Coogle 25 Origiral from UNIVERSITY OF MICHIGAN sionally of the sweat and lacrimal glands.
The Thymus, Manganese and Myasthenia Gravis, Incorporating Myasthenia Gravis, Manganese and THF Thymus by Emanuel M. Josephson
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