By W. John W. Morrow, Nadeem A. Sheikh, Clint S. Schmidt, D. Huw Davies
ISBN-10: 1405185740
ISBN-13: 9781405185745
Masking all points of vaccine learn and improvement in a single quantity, this authoritative source takes a complete and systematic method of the technological know-how of vaccinology focusing not just on easy technology, but additionally at the many phases required to commercialize and navigate the regulatory standards for human program, either within the usa and Europe.
Reviews intimately the method of designing a vaccine, from the preliminary phases of antigen discovery to human application
Includes overview of vaccine efficacy and safety
Details scientific trial layout, together with regulatory requirements
Discusses the rising box of lively mobile immunotherapy
Vaccinology: ideas and perform offers a useful source for clinicians, clinical and clinical researchers, academics and postdoctoral fellows operating within the box of vaccines.
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Extra info for Vaccinology: Principles and Practice
Sample text
93 Querec T, Bennouna S, Alkan S, et al. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med 2006;203(2):413–24. 94 Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 95 96 97 98 99 100 101 102 103 104 105 1-polarizing program in dendritic cells. Nat Immunol 2005;6(8):769–76. Ioannou XP, Gomis SM, Karvonen B, et al.
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003; 170(10):5165–75. Roman M, Martin-Orozco E, Goodman JS, et al. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 1997; 3(8):849–54. Schulz O, Diebold SS, Chen M, et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005;433(7028):887–92. Heit A, Huster KM, Schmitz F, et al. CpG-DNA aided cross-priming by cross-presenting B cells.
Formalin-inactivated respiratory syncytial virus (FI-RSV) vaccine given to children in the 1960s [101–103] was not protective and even enhanced clinical disease, sometimes resulting in death, after subsequent exposure to RSV. In this case both the inactivation procedure and the adjuvant likely played a role in the induction of a non-neutralizing Th2-biased response. T-helper type 2-dominant immune responses are also associated with allergy, asthma, and autoimmune disease [104,105]. Thus, safe but effective adjuvants are urgently needed for future vaccines.
Vaccinology: Principles and Practice by W. John W. Morrow, Nadeem A. Sheikh, Clint S. Schmidt, D. Huw Davies
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