By A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)
The challenge of senescence, as mirrored within the heritage of reli gion and philosophy, has lengthy been one of many maximum issues of humankind. against this, gerontology as a department of technological know-how continues to be relatively younger. in past times decade, concomitant with fast development in our knowing of the elemental existence sciences, sizeable shops of information approximately organic getting older were collected. this information, notwithstanding, bobbing up from many clinical disciplines and inquisitive about various degrees of biologic association, turns out nearly random and covers every little thing from molecules to human societies. Theories complex to interpret the proof and to appreciate the mech anisms serious about senescence have remained in person, instead of basic, territories. It has lengthy been felt via a few gerontologists that it used to be time for many of the experts to step again and take a generalist view of gerontology, to re-evaluate and reevaluate the culmination in their analyt ical objectives at varied degrees inside a broader context. a few others might imagine it nonetheless untimely. It appeared, although, that almost all of these who collected in Tokyo at the celebration of the XIth foreign Congress of Gerontology have been of the opinion that there has been a lot to be received in trying to find interrelationships one of the evidence and theories originated within the varied degrees of investiga tion in an try to detect and savour the organic drama of senescence as an entity.
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Extra resources for Aging Phenomena: Relationships among Different Levels of Organization
Specific Activity ...... ~ ...... ~ .. ~ u oCt z -... 40 a ...... 'a 70 E E u u fa 30 50 20 1. o 3 Fig. 3. 3 o I months 18 I 23 Changes of sulfotransferase activity with aging. The enzyme activity using chondroitin as sulfate acceptor was determined by the method of Habuchi et ale (11). For further experimental details, see reference (5). Results indicate mean! E. (n = 3 or 4). The tota~ activity of sulfotransferase was defined as cpm/g cartilage/hr incorporated into chondroitin. The specific activity of sulfotransferase was defined as cpm/mg DNA/hr incorporated into chondroitin.
Yamada, Age-related decline in Hi histone fraction in human diploid fibroblast cultures, Exp. , in press. CHANGE OF RESPONSIVENESS TO GROWTH STIMULATION OF NORMAL CELLS DURING AGING Tadao Ohno National Institute of Radiological Sciences Anagawa, Chiba-shi 260 Japan INTRODUCTION The sole determinant of life span of normal diploid cells in vitro has been considered to be the intrinsic doubling number of the cells (1,2,3). Recent investigations, however, suggest that extracellular factors can affect the proliferative potential of the cells.
When liver cells were trypsinized and plated, a small proportion of the cells formed colonies of varying sizes within two weeks of incubation. The proportion of multinucleated cells was higher in small colonies than it was in large colonies. T. MATSUMURA • ®-e 35 Stem cell Prolde .. "nq loneoqe Fig. 3. A hypothetical scheme for the proliferation and multinucleation of cultured human liver cells. The cells at the bottom are the descendants of a single cell, shown at the top. Clonogenic cells are represented by cells with filled nuclei.
Aging Phenomena: Relationships among Different Levels of Organization by A. Macieira-Coelho (auth.), Kunio Oota, Masami Iriki, Takashi Makinodan, Lynn S. Baker (eds.)