ISBN-10: 0199695547
ISBN-13: 9780199695546
This case-based studying ebook information 25 demanding instances in cardiovascular drugs masking all subspecialty components of cardiology. it truly is designed for use through trainees yet every one case is supported through the observation of a popular specialist within the box, permitting readers to enhance their very own administration of those patients.
As the reader works via every one case there are 'Clinical Tips', 'Learning Points' and 'Landmark Trial Summaries' to augment the educational procedure besides the 'Expert Commentary', delivering an inside of tune on how the specialists process these kinds of hard situations.
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Extra info for Challenging Concepts in Cardiovascular Medicine: Cases with Expert Commentary
Sample text
The purpose of the study was to demonstrate that PCI was non-inferior to CABG in this patient subset. The trial was stopped early due to slow enrolment and as such, the event rates used for sample size calculations could not be achieved. Nevertheless, the incidence of the primary endpoint of death, non-fatal MI, and non-fatal stroke at one year was similar for both strategies although non-inferiority could not be proven. There was again a significant reduction in the incidence of repeat revascularization for those having had CABG.
All observations were normal as was a troponin T and repeat ECG that showed no acute ischaemia. The patient was discharged home later that evening. Learning point The evolution of dual antiplatelet therapy The central role of platelets in the propagation of intracoronary thrombi has made antiplatelet therapy central to the management of atherothrombotic cardiovascular disease. Over the last two decades, aspirin has become the cornerstone of antiplatelet therapy [1]. Its antithrombotic action is mediated through the irreversible acetylation of cyclooxygenase (COX) enzymes secreted by activated platelets.
The purpose of the study was to demonstrate that PCI was non-inferior to CABG in this patient subset. The trial was stopped early due to slow enrolment and as such, the event rates used for sample size calculations could not be achieved. Nevertheless, the incidence of the primary endpoint of death, non-fatal MI, and non-fatal stroke at one year was similar for both strategies although non-inferiority could not be proven. There was again a significant reduction in the incidence of repeat revascularization for those having had CABG.
Challenging Concepts in Cardiovascular Medicine: Cases with Expert Commentary
by Ronald
4.4