By Dirk ter Haar
ISBN-10: 0030559952
ISBN-13: 9780030559952
Thermostatistics is a topic that may be fruitfully studied if plenty of different topics in physics are good understood. it's going to be assumed that the reader is definitely accustomed to classical mechanics, quantum idea, thermodynamics, and calculus.
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Additional resources for Elements of Thermostatistics, Second Edition
Example text
51), respectively, for a situation where k m is greater than K. 1 lOne-Compartment Model 23 Antipyrine half-life (h) Fig. 12 Correlation between the half-life of antipyrine determined by following the decline of drug concentrations in plasma and that determined from a semilogarithmic plot of the urinary excretion rate of an antipyrine metabolite, 4-hydroxyantipyrine, versus time in individual patients. It is evident that the elimination rate constant of the metabolite, k m, is significantly larger than the elimination rate constant of antipyrine, K.
G. R. Wilkinson and A. H. Beckett. Absorption, metabolism and excretion of the ephedrines in man: I. The influence of urinary pH and urine volume output. J. Pharmacol. Exp. Ther. 162:139 (1968) . 5. J. A. Taylor. Pharmacokinetics and biotransformation of chlorpropamide in man. Glin. Pharmacol. Ther. 13: 710 (1972). 6. W. H. Barr, L. M. Gerbracht, K. Letcher, M. Plaut, and N. Strahl. Assessment of the biologic availability of tetracycline products in man. Glin. Pharmacol. Ther. 13: 97 (1972). 7.
28: 262 (1980). 14. P. J. McNamara, W. A. Colburn. and M. Gibaldi. Absorption kinetics of hydroflumethiazide. J. Clin. Pharmacol. 18:190 (1978) . 2 Multicompartment Models Most drugs entering the systemic circulation require a finite time to distribute fully throughout the available body space. This fact is particularly obvious upon rapid intravenous injection. During this distributive phase, drug concentration in the plasma will decrease more rapidly than in the postdistributive phase. Whether or not such a distributive phase is apparent depends on the frequency with which blood samples are taken.
Elements of Thermostatistics, Second Edition by Dirk ter Haar
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