By Carlos A. Perez MD, Srinivasan Vijayakumar MD (auth.), Seymour H. Levitt MD, James A. Purdy PhD (eds.)
This publication, now in its fourth version, is exclusive in detailing extensive the technological foundation of radiation treatment. in comparison with the former variation, all chapters were rewritten and up to date. additionally, new chapters were incorporated on a number of issues, together with using imaging in therapy making plans, moment malignant neoplasms because of irradiation, and caliber coverage in radiation oncology. The e-book is split into sections. the 1st covers easy strategies in remedy making plans, together with crucial physics, and explains a number of the ways to radiation treatment, corresponding to intensity-modulated radiation remedy, tomotherapy, and low and high dose fee brachytherapy. the second one half files the sensible scientific purposes of those strategies within the remedy of other cancers. all the chapters were written by way of leaders within the box. This ebook will serve to teach and acquaint lecturers, scholars and practitioners within the a number of fields of oncology with the elemental technological elements and techniques in radiation therapy.
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Extra resources for Technical Basis of Radiation Therapy: Practical Clinical Applications
3 Gy in 2001 when updated with more patients and centers (Fowler et al. 2001). Some other estimates have however suggested DE to be about 3 Gy, similar to the commonly accepted DE ratio for late rectal complications (Wang et al. 2003; Kal and van Gellekom 2003). 8 Gy or 2 Gy fractions). That estimate of prostate tumor DE of about 3 Gy, however, assumed that prostate tumor cells repopulate as rapidly as head-and-neck tumors. We did not agree with this assumption (Fowler et al. 2003a) and still do not (Dasu and Fowler 2005).
An overview of 63 clinical trials covering 10,741 patients reported an average survival benefit at 2 years and 5 years of 4%. The equivalent in terms of extra radiation dose in concomitant chemoradiotherapy is reported to be two or three extra 2 Gy fractions, by which the total dose has to be reduced to keep the acute reactions tolerable. 2 Gy10, which is 5–7% of the total log cell kill by radiotherapy. A survival benefit averaging 4% or 5% is rather less than expected from this estimate. Whether this additional tumor effect is obtained with no more than an equivalent extra effect in normal-tissue acute (or any) reactions remains to be determined by more detailed clinical observations.
Int J Radiat Oncol Biol Phys 23:457–467 Fowler JF, Chappell RJ, Ritter MA (2001) Is DE for prostate tumors really low? Int J Radiat Oncol Biol Phys 50:1021– 1031 Fowler JF, Ritter MA, Fenwick JD, Chappell RJ (2003a) How low is the DE ratio for prostate cancer? In regard to Wang et al 2003. IJROBP 55:194–203 Fowler JF, Ritter MA, Chappell RJ, Brenner JD (2003b) What hypofractionated protocols should be tested for prostate cancer? Int J Radiat Oncol Biol Phys 56:1093–1104 Fowler JF, Harari PM, Leborgne F, Leborgne JH (2003c) Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedules.
Technical Basis of Radiation Therapy: Practical Clinical Applications by Carlos A. Perez MD, Srinivasan Vijayakumar MD (auth.), Seymour H. Levitt MD, James A. Purdy PhD (eds.)