By Peter Morris MD PhD FRS FRCS, Stuart J. Knechtle MD FACS
ISBN-10: 1455740969
ISBN-13: 9781455740963
With meticulous updates all through, Kidney Transplantation is still your definitive scientific source for state-of-the-art answers on each element of renal transplantation. A multidisciplinary process from the world over well known nephrologists from all over the world bargains practice-applicable guidance for all contributors of the transplant group. With insurance encompassing utilized technology, surgical thoughts, immunosuppressive equipment, results, hazards, and scientific concerns with regards to kidney transplantation, either in adults and kids, you should have the balanced information you want to in attaining the very best results.
- Visualize key suggestions and parent nuances of renal transplantation ideas via greater than 335 very good illustrations.
- Access the totally searchable textual content online at any place, each time with Expert Consult on-line access.
- Apply the most recent wisdom and techniques with state of the art insurance of all components of kidney transplantation similar to upkeep of kidneys; mechanisms of rejection and the induction of tolerance; innovations of laparoscopic stay donor nephrectomy; and immunosuppression.
- Stay current with new chapters on Belatacept; kidney paired donation courses for residing donors; and facts in transplantation, plus complete updates throughout.
- Hone your wisdom and medical talents with new video clips at Expert seek advice that display the formation of an immune synapse, 3D rotational photos of immune synapses, an NK phone killing its goal, peritoneal dialysis-catheter insertion strategies, mind dying exam, and extra.
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Extra resources for Kidney Transplantation - Principles and Practice: Expert Consult - Online and Print, 7e
Example text
DC subsets can be defined on the basis of their localization, morphology, cell surface, and functional phenotypes. A detailed description of their different roles is beyond the scope of this chapter; however other aspects of their functions will be discussed. Classical DCs exhibit a so-called immature phenotype characterized by a high level of antigen uptake but relatively low levels of cell surface MHC and costimulatory molecule expression. Their subsequent maturation is accompanied by upregulation of these cell surface molecules, migration to secondary lymphoid organs and, generally, secretion of proinflammatory cytokines.
The role of DCs is however wide-ranging, playing a crucial 20 Kidney Transplantation: Principles and Practice role in immunological tolerance285 and tuning adaptive immunity to ensure different effector mechanisms are used efficiently. DC subsets can be defined on the basis of their localization, morphology, cell surface, and functional phenotypes. A detailed description of their different roles is beyond the scope of this chapter; however other aspects of their functions will be discussed. Classical DCs exhibit a so-called immature phenotype characterized by a high level of antigen uptake but relatively low levels of cell surface MHC and costimulatory molecule expression.
Their subsequent maturation is accompanied by upregulation of these cell surface molecules, migration to secondary lymphoid organs and, generally, secretion of proinflammatory cytokines. 153 Pattern recognition by DCs seems not simply to involve the detection of “danger” but also “safety” (under non-inflamed conditions); they integrate a range of signals that maintain an immature, tolerogenic phenotype. These pathways and associated intracellular signaling230 are only now being explored; they seem to involve molecules such as ILT3 and ILT4, Fc receptors (which can be activating (FcγRIII) or inhibitory (FcγRIIB)) and C-type lectins (which also can be activating or inhibitory).
Kidney Transplantation - Principles and Practice: Expert Consult - Online and Print, 7e by Peter Morris MD PhD FRS FRCS, Stuart J. Knechtle MD FACS
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